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<?php
/**
 * Copyright © Magento, Inc. All rights reserved.
 * See COPYING.txt for license details.
 */

$storeId = \Magento\TestFramework\Helper\Bootstrap::getObjectManager()->get(
    \Magento\Store\Model\StoreManagerInterface::class
)->getDefaultStoreView()->getId();
/** @var $change \Magento\Theme\Model\Design */
$change = \Magento\TestFramework\Helper\Bootstrap::getObjectManager()->create(\Magento\Theme\Model\Design::class);
$change->setStoreId($storeId)->setDesign('Magento/luma')->setDateFrom('2001-01-01 01:01:01')->save();